04/04/24Sanford Burnham Prebys Human Brain Small Extracellular Vesicles Contain Selectively Packaged, Full-Length mRNA Paper of the Week Read more
03/26/24Sanford Burnham Prebys Angela Liou tackles pediatric brain tumors head-on Press Release Read more
03/25/24Sanford Burnham Prebys Sanford Burnham Prebys Cancer Center seminar on March 25 Blog Read more
03/25/24Sanford Burnham Prebys Seminar Series: extrachromosomal DNA and the metabolic circuits of cancer immune suppression Blog Read more
03/13/24Sanford Burnham Prebys Xueqin Sun seeks to illuminate the underlying causes of cancer Press Release Read more
03/06/24Salk Institute A step towards clinic-ready patient-derived organoids LA JOLLA—Pancreatic cancer has the highest mortality rate of all major cancers and is projected to become the second-leading cause of cancer-related deaths in the United States by 2030. It is especially difficult to treat because pancreatic tumors grow so quickly and are constantly evolving, making them prone to developing drug resistance. Read more
02/28/24Salk Institute More than just neurons: A new model for studying human brain inflammation LA JOLLA—The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain. The other half—roughly 85 billion cells—are non-neuronal cells called glia. The most common type of glial cells are astrocytes, which are important for supporting neuronal health and activity. Despite this, most existing laboratory models of the human brain fail to include astrocytes at sufficient levels or at all, which limits the models’ utility for studying brain health and disease. Read more
02/08/24Salk Institute Faulty DNA disposal system causes inflammation LA JOLLA—Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that mitochondria use to create life-giving energy. When mtDNA remains where it belongs (inside of mitochondria), it sustains both mitochondrial and cellular health—but when it goes where it doesn’t belong, it can initiate an immune response that promotes inflammation. Read more
02/07/24Salk Institute Lung cancer hijacks immune cell metabolism to fuel its own growth LA JOLLA—Lung adenocarcinoma is the most common lung cancer and the cause of most cancer-related deaths in the United States. There are several ways lung adenocarcinoma can arise, one of which is a mutation in a protein called EGFR (epidermal growth factor receptor). Non-mutated EGFR helps cells grow in response to injury, but mutated EGFR promotes out-of-control growth that can turn into cancer. Modern immunotherapies don’t work against EGFR-driven lung adenocarcinoma, and while some drugs exist to treat the cancer, patients typically develop a resistance to them within just a few years. This gap in the treatment toolchest inspired Salk Institute researchers to probe for weak spots in the cancer’s growth pathway. Read more
01/25/24Salk Institute Salk Institute names Jan Karlseder as Chief Science Officer LA JOLLA—The Salk Institute has named Jan Karlseder as its new senior vice president and chief science officer (CSO). Karlseder, a professor in Salk’s Molecular and Cell Biology Laboratory, director of the Paul F. Glenn Center for Biology of Aging Research, and Donald and Darlene Shiley Chair for Research on Aging, will assume the role on February 1, 2024. Read more
01/17/24Salk Institute Salk researchers earn $1.3 million W. M. Keck Foundation award to study aging brain LA JOLLA—Salk Institute Professor Rusty Gage and Assistant Professor Pallav Kosuri have been awarded $1.3 million by the W. M. Keck Foundation to fund a novel investigation into the way brain and heart cell functions decline over time due to ribosubstitution events—cellular repair of DNA damage with RNA building blocks rather than DNA building blocks. The award combines the biological discovery of ribosubstitution made by Senior Research Associate Jeff Jones in Gage’s lab with the technological advancements established by Postdoctoral Researcher Yuening Liu in Kosuri’s lab. The W. M. Keck Foundation was established with the goal of generating far-reaching benefits for humanity by supporting outstanding science, engineering, and medical research. Read more
12/13/23Salk Institute Salk teams assemble first full epigenomic cell atlas of the mouse brain LA JOLLA—Salk Institute researchers, as part of a worldwide initiative to revolutionize scientists’ understanding of the brain, analyzed more than 2 million brain cells from mice to assemble the most complete atlas ever of the mouse brain. Their work, published December 13, 2023 in a special issue of Nature, not only details the thousands of cell types present in the brain but also how those cells connect and the genes and regulatory programs that are active in each cell. Read more