09/23/21Salk Institute Peter Adams and Gerald Shadel awarded $13 million from NIH to study aging and liver cancer LA JOLLA—Sanford Burnham Prebys Professor Peter D. Adams, who directs the Aging, Cancer and Immuno-oncology Program, and Salk Institute Professor Gerald Shadel, who directs the San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, have been awarded a grant from the NIH’s National Institute on Aging for $13 million, funding a five-year project to explore the connection between aging and liver cancer. Read more
09/23/21Sanford Burnham Prebys Peter Adams and Gerald Shadel awarded $13 million from NIH to study aging and liver cancer Press Release Read more
09/16/21Salk Institute The Salk Institute and Sanford Burnham Prebys licenses ULK1/2 inhibitors to Endeavor BioMedicines for treatment of cancer LA JOLLA—The Salk Institute, along with Sanford Burnham Prebys, have signed an exclusive licensing agreement with California-based Endeavor BioMedicines for an intellectual property portfolio relating to cancer therapeutics and diagnostics that target ULK1/2, a protein involved in cellular recycling, jointly developed by researchers at Salk and Sanford Burnham Prebys. The negotiations were led by the Salk Office of Technology Development and the Sanford Burnham Prebys Business Development Office. Read more
08/25/21Salk Institute Axel Nimmerjahn leads research team awarded $11 million by the U19 Team-Research BRAIN Circuit Program LA JOLLA—Salk Associate Professor Axel Nimmerjahn is leading a research team that has been awarded $11.2 million by The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, an effort that aims to investigate overarching principles of brain circuit function, including sensation, perception, decision-making and motor control. Nimmerjahn will lead an interdisciplinary five-year project investigating how astrocytes, star-shaped cells in the brain, process and modulate signals from neurons to better understand overall brain function. Read more
08/19/21Salk Institute Salk promotes Diana Hargreaves to associate professor LA JOLLA—The Salk Institute has promoted Diana Hargreaves to the rank of associate professor for her notable contributions in epigenetic regulation, which make specific regions of our DNA accessible to the machinery of cells. The promotion was based on recommendations by Salk faculty and nonresident fellows, and approved by President Rusty Gage and the Institute’s Board of Trustees. Read more
06/10/21Salk Institute “Bad fat” suppresses killer T cells from attacking cancer LA JOLLA—In order for cancer to grow and spread, it has to evade detection by our immune cells, particularly specialized “killer” T cells. Salk researchers led by Professor Susan Kaech have found that the environment inside tumors (the tumor microenvironment) contains an abundance of oxidized fat molecules, which, when ingested by the killer T cells, suppresses their ability to kill cancer cells. In a vicious cycle, those T cells, in need of energy, increase the level of a cellular fat transporter, CD36, that unfortunately saturates them with even more oxidized fat and further curtails their anti-tumor functions. Read more